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Thursday, November 19, 2009

Turkey Consumption May Prevent Shoppers Trampling Each Other in Consumerist Frenzy

Posted by Bethany Jean Clement on Thu, Nov 19, 2009 at 10:23 AM

Calming.
  • mraaronmorris / Stranger Flickr
  • Calming.

At least according to a husband-and-wife team of assistant professors of marketing at the University of Utah's David Eccles School of Business.

The researchers approached study participants between 7 p.m. and 11 p.m. on a Thanksgiving holiday and asked them to fill out an online questionnaire. "We found that participants who had consumed a traditional Thanksgiving dinner with turkey displayed less willingness to buy deeply discounted products compared to those who did not consume a traditional dinner," Himanshu Mishra said.

They conclude that higher levels of tryptophan, which increase the ol' serotonin levels, make one less impulsive, e.g., less trampley when the WalMart opens the day after Thanksgiving.

But: Might there also be other factors in play here?

Meanwhile, in useful sense-making Thanksgiving news, our local and thoroughly awesome Questionland Experts are answering queries about giblets, desserts that are more interesting than pumpkin pie, and (ever-popular) booze. Yes!

A Gorilla Names Its Baby

Posted by Charles Mudede on Thu, Nov 19, 2009 at 8:36 AM

My problem with this report?

A baby gorilla at the Toronto Zoo has his father — and fruit — to thank for his new name.

As more than 50 people watched yesterday morning, five names — each next to its own enticing treat — were put to Charles (pictured above). After surveying the lot, Charles lumbered straight over to the container marked ‘Nassir’ — alongside some select apples, pears and oranges.

The five potential names — Nassir, Neo, Nico, Nigel and Nsambu — were selected through a contest. The contest required the name begin with the letter N, to honour his mother, Ngozi.

Yes, the name of Nassir's father. Who gave that beast that pleasant-sounding, so civilized name? Knuckles, Dak, Ton, Kong, Mud, Brut—these names are appropriate for an animal that's all muscle and hair.


One other comment. Though it's hard to imagine, but for a considerable part of history, very deep history, a human was to see, in his/her lifetime, far more gorillas or chimps than other human beings. Today, all we see are humans, humans, humans.

Wednesday, November 18, 2009

You Look Good Enough to Eat

Posted by Bethany Jean Clement on Wed, Nov 18, 2009 at 12:51 PM

Over at h+ magazine's blog, it's "Eight Ways In-Vitro Meat will Change Our Lives," about how meat grown in a lab instead of on the hoof will liberate us all. Among the eight ways: no more animal-to-human plagues, former ranch land given over to waving fields of hemp, fewer greenhouse gasses due to the end of all those animal emissions, and...

6: Exotic & Kinky Cuisine.

In-Vitro Meat will be fashioned from any creature, not just domestics that were affordable to farm. Yes, ANY ANIMAL, even rare beasts like snow leopard, or Komodo Dragon. We will want to taste them all. Some researchers believe we will also be able to create IVM using the DNA of extinct beasts — obviously, "DinoBurgers" will be served at every six-year-old boy's birthday party.

Humans are animals, so every hipster will try Cannibalism. Perhaps we'll just eat people we don't like, as author Iain M. Banks predicted in his short story, "The State of the Art" with diners feasting on "Stewed Idi Amin." But I imagine passionate lovers literally eating each other, growing sausages from their co-mingled tissues overnight in tabletop appliances similar to bread-making machines. And of course, masturbatory gourmands will simply gobble their own meat.

Now it is time for lunch.

Tuesday, November 17, 2009

World Not Ending in 2012

Posted by Eli Sanders on Tue, Nov 17, 2009 at 9:27 AM

Phew.

Monday, November 16, 2009

Another Research Shocker: Lesbian Edition

Posted by Bethany Jean Clement on Mon, Nov 16, 2009 at 10:20 AM

For all those unaware that lesbians take better care of their cats than most straight people take care of their children, research has now officially shown that "Lesbians Make 'Better Parents.'"

Research at Birkbeck College, part of London University, and Clark University in Massachusetts suggests that same-sex couples make good parents because children cannot be conceived accidentally—parents must make an active decision to adopt or find a sperm donor.

Go figure!

This article has some more information.

Thanks, Slog tippers laura and Jason in Portland.

Friday, November 13, 2009

There Is Water on the Moon!

Posted by Charles Mudede on Fri, Nov 13, 2009 at 10:24 AM

Not only is whitey on the moon:

(CNN) NASA said Friday it had discovered water on the moon, opening "a new chapter" that could allow for the development of a lunar space station.

The discovery is based on preliminary data collected when the Lunar Crater Observation and Sensing Satellite, or LCROSS, intentionally crashed October 9 into the permanently shadowed region of Cabeus crater near the moon's south pole.

One day the rich will be able to take a bath on the balcony of the earth, the moon.

Wednesday, November 11, 2009

CERN's Large Hadron Collider Encounters Bird Food From the Future?

Posted by Charles Mudede on Wed, Nov 11, 2009 at 10:06 AM

Slog reader Jeff Yencho just asked me to comment on this piece of news ("I read this today and thought 'geez, I'd love to hear Charles' take on this...'"):

Sometime on Nov. 3, the supercooled magnets in sector 81 of the Large Hadron Collider (LHC), outside Geneva, began to dangerously overheat. Scientists rushed to diagnose the problem, since the particle accelerator has to maintain a temperature colder than deep space in order to work. The culprit? "A bit of baguette," says Mike Lamont of the control center of CERN, the European Organization for Nuclear Research, which built and maintains the LHC. Apparently, a passing bird may have dropped the chunk of bread on an electrical substation above the accelerator, causing a power cut. The baguette was removed, power to the cryogenic system was restored and within a few days the magnets returned to their supercool temperatures.

While most scientists would write off the event as a freak accident, two esteemed physicists have formulated a theory that suggests an alternative explanation: perhaps a time-traveling bird was sent from the future to sabotage the experiment.


First, Jeff, time travel is not possible. A little philosophical thinking will make that clear to anyone. Two, you should not look to the future to make any sense of this bird but to the past. In the past, there exists another big science project that had a problem with a bird (or actually birds). This particular project led to the discovery (the accidental discovery) of the cosmic microwave background, the birth of the universe, and the substance of the Big Bang theory. The birds involved in that science project, however, had digested the food that caused the problem.

From Wikipedia:

[In 1962, two physicists (Penzias worked with Wilson) began working in Holmdel, New Jersey] on ultra-sensitive cryogenic microwave receivers intended for radio astronomy observations.

In 1964, on building their most sensitive antenna/receiver system, Penzias and Wilson encountered radio noise that they could not explain. It was far less energetic than the radiation given off by the Milky Way, and it was isotropic, so they assumed their instrument was subject to interference by terrestrial sources. They tried, and then rejected, the hypothesis that the radio noise emanated from New York City. An examination of the microwave horn antenna showed it was full of pigeon droppings (which Penzias described as "white dielectric material"). After the pair removed the guano buildup, and the pigeons were shot (each physicist says the other ordered the deed), the noise remained. Having rejected all sources of interference, the pair published a paper announcing their findings. This was later identified as the cosmic microwave background radiation (CMB), the radio remnant of the Big Bang. This allowed astronomers to confirm the Big Bang, and to correct many of their previous assumptions about it.

This account is almost correct. The scientists had tried to relocate the birds (five in all) 30 or so miles from the antenna/receiver but two returned—those two were shot.

But, Jeff, do you see the cosmic connection? The scientist heard the birth of the universe and thought it was bird shit. What, in the case of the Hadron Collider, are we to make of this piece of undigested bird food? It cannot, I think, be separated from the bird shit that was once on the antenna/receiver system.

Tuesday, November 10, 2009

There's No Place Like Dome

Posted by Paul Constant on Tue, Nov 10, 2009 at 4:39 PM

Today is the national release date for Stephen King's nearly 1100-page novel Under the Dome, in which a giant impenetrable dome mysteriously appears over a small town in Maine. I'll have a review of the book in tomorrow's paper, but in the meantime, H+ Magazine informs us that officials in a small town in Vermont actually considered building a giant dome over their town in the 1970s:

9781439148501.jpg
In the late 1970s the U.S was in its second energy crisis of the decade and roiled by double-digit inflation. Oil was at a then-shocking $38 a barrel ($107 in today’s dollars), having risen eightfold in the previous ten years, and Jimmy Carter went on television in a Cardigan sweater to urge Americans to turn down their thermostats. Few towns were hurting more than frigid Winooski, whose residents spent about $4 million a year to stay thawed.

One night in 1979 a group of its creative young city planners went to dinner and Mark Tigan, then the city’s 32-year-old director of community development and planning, decided that not enough attention was being paid to energy conservation. Then, in the way that only a few glasses of wine can facilitate brainstorming, someone said, half tongue-in-cheek, they should put a dome over the city.

The next morning it still seemed like a good idea — or, at least, not necessarily completely absurd...Tigan had his staff prepare a white paper on the dome. They wrote that a one square mile dome would reduce resident’s heating bills by up to 90 percent. Tigan presented the idea to the city council. Clem Bissonette, then on Winnoski’s city council and now its ex-mayor, asked Tigan, “Are you nuts?

This all sounds like it could be a hoax, but this Time Magazine story from 1979 seems to imply that it was true. I bet if Fox News was around in the Carter administration, "Dome, Baby, Dome!" would have been the "Drill, Baby, Drill!" of the energy crisis.

We Can Rebuild You

Posted by Dan Savage on Tue, Nov 10, 2009 at 9:48 AM

BBC:

Tissue created in a laboratory has been used to completely replace the erectile tissue of the penis in animals. The advance raises hopes of being able to restore full function to human penises that have been damaged by injury or disease.... Professor Anthony Atala said: "Further studies are required, of course, but our results are encouraging and suggest that the technology has considerable potential for patients who need penile reconstruction.

"Our hope is that patients with congenital abnormalities, penile cancer, traumatic injury and some cases of erectile dysfunction will benefit from this technology in the future."

This could also be good news for female-to-male transsexuals.

Thursday, November 5, 2009

Percentages and Vote Counts

Posted by Jonathan Golob on Thu, Nov 5, 2009 at 6:31 PM

Today was a good day for McGinn, right? The difference in vote counts went up from yesterday, from 462 to 515. Fifty-three more votes went to McGinn.

Counts in the way of McGinn!
  • Counts in the way of McGinn

Wrong.

This is one of the most annoying fallacies of election reporting. While the final result is determined by the absolute counts, as we're using the ongoing vote totals as a sample of that final count we should be paying attention to percentages. By this more accurate measure, the mayoral race has tightened a bit since yesterday, from 0.44% to 0.40% (when excluding write-ins from the total).

... but the percentage tightens
  • ... but the percentage tightens

Given the (innovative in city elections) use of last-minute get out the vote efforts by the McGinn campaign, I suspect these ongoing totals might not be as reflective of the true final counts as in the past. But for now, today's results are actually looking better for Mallahan, not worse.

(Don't even get me started about the foolishness of expecting machine or hand recounts to resolve an election whose final counts are within the margin of counting error. We might as well just flip a coin, if we're going to rely upon entropy to make our decisions.)

Wednesday, November 4, 2009

News from the Animal Kingdom: Some Animals Can Display Grief for the Dead

Posted by Charles Mudede on Wed, Nov 4, 2009 at 9:29 AM

Here is how gorillas grieve:

Gorillas are known to hold wakes for dead friends, something that some zoos have formalized in a ceremony when one of their gorillas passes away. Donna Fernandes, now president of the Buffalo Zoo, tells the story of being at Boston's Franklin Park Zoo ten years ago during the wake for a female gorilla, Babs, who had died of cancer. She describes seeing the gorilla's longtime mate say good-bye: "He was howling and banging his chest,... and he picked up a piece of her favorite food — celery — and put it in her hand and tried to get her to wake up. I was weeping, it was so emotional." Later, the scene at Babs's December funeral was similarly moving. As reported by local news, gorilla family members "one by one ... filed into" the room where "Babs's body lay," approaching their "beloved leader" and "gently sniffing the body."

Here is how elephants express their grief:

[These] are the actions of the members of an elephant family... after a group member had been shot: "Teresia and Trista became frantic and knelt down and tried to lift her up. They worked their tusks under her back and under her head. At one point they succeeded in lifting her into a sitting position but her body flopped back down. Her family tried everything to rouse her, kicking and tusking her, and Tullulah even went off and collected a trunkful of grass and tried to stuff it in her mouth."

Finally, wolves:

[A] wolf pack after the loss of the low-ranking omega female wolf, Motaki, to a mountain lion. The pack lost their spirit and their playfulness. They no longer howled as a group, but rather they "sang alone in a slow mournful cry." They were depressed — tails and heads held low and walking softly and slowly — when they came upon the place where Motaki was killed. They inspected the area and pinned their ears back and dropped their tails, a gesture that usually means submission. It took about six weeks for the pack to return to normal. The Dutchers also tell of a wolf pack in Canada in which one pack member died and the others wandered about in a figure eight as if searching for her. They also howled long and mournfully.

As for humans, some of us can completely contain our emotions and turn the grief into a dark, inner sea that's wide and deep. We know the depths of death. No crying, no smelling, no stomping about—just the silent sea of grief.

Almost All of the Universe Is Dark

Posted by Charles Mudede on Wed, Nov 4, 2009 at 8:13 AM

Just 5% of everything is normal:

A detailed picture of the seeds of structures in the universe has been unveiled by an international team co-led by Sarah Church of the Kavli Institute for Particle Astrophysics and Cosmology, jointly located at the Department of Energy's SLAC National Accelerator Laboratory and Stanford University, and by Walter Gear, of Cardiff University in the United Kingdom. These measurements of the cosmic microwave background — a faintly glowing relic of the hot, dense, young universe — put limits on proposed alternatives to the standard model of cosmology and provide further support for the standard cosmological model, confirming that dark matter and dark energy make up 95% of everything in existence, while ordinary matter makes up just 5%
Such discoveries, discoveries that decenter and belittle humans, gives us a terrific sense of what Terry Eagleton calls "the sublime negative." To use Martin Rees words: "The distinctive details of our universe, and of everything in it (ourselves included), seem to be the outcome of what might be called an accident."

From the accident of the universe, the sublime negativity itself, we get this other accidental universe, the accident of Miss Universe 2009:

Picture_2.png
Even her dress is a universe.

Wednesday, October 28, 2009

Red in...

Posted by Charles Mudede on Wed, Oct 28, 2009 at 9:54 AM

If you hate mosquitoes as much as I do, you will draw as much pleasure as I did from this image for this Science News story:

A jumping spider feasts on a mosquito, living up to researchers' nickname of "Mosquito Terminator" for this Evarcha culicivora spider. Eating a mosquito engorged on blood makes both males and females of this species more appealing to potential mates
.

The Other Way Around

Posted by Charles Mudede on Wed, Oct 28, 2009 at 9:26 AM

Nonstop is the news about diseases jumping from other animals (birds, pigs) to us (frightful!). For once, a story about diseases jumping from us to other animals:

Researchers from The Roslin Institute of the University of Edinburgh have shown that a strain of bacteria has jumped from humans to chickens.

It is believed to be the first clear evidence of bacterial pathogens crossing over from humans to animals and then spreading since animals were first domesticated some 10,000 years ago.

The study identified a form of the bacteria Staphylococcus aureus — of which MRSA is a subtype — in chickens, and found that the bacteria originally came from humans.

Monday, October 26, 2009

Recently on Mars

Posted by Grant Brissey on Mon, Oct 26, 2009 at 3:23 PM

dustdevils.jpg
  • NASA, HiRISE, MRO, LPL (U. Arizona)
  • (Click to enlarge image)

This high-resolution picture from the HiRISE camera on board the Mars Reconnaissance Orbiter shows twisting dark trails criss-crossing light-colored terrain on the Martian surface. Newly formed trails like these had presented researchers with a tantalizing mystery but are now known to be the work of miniature wind vortices known to occur on the red planet, in other words Martian dust devils. Such spinning columns of rising air heated by the warm surface are also common in dry and desert areas on planet Earth. Typically lasting only a few minutes, dust devils become visible as they pick up loose red-colored dust leaving the darker and heavier sand beneath intact. Ironically, dust devils have been credited with unexpectedly cleaning the solar panels of the Mars rovers.

h/t: nasa.gov and Slog commenter Peter F.

Friday, October 23, 2009

Flying Anvils Are Incredibly Satisfying

Posted by Paul Constant on Fri, Oct 23, 2009 at 2:30 PM

Here, via Super Punch, we have someone who enjoys launching anvils some 200 feet into the air:

Thursday, October 22, 2009

Who Rules the World?

Posted by Charles Mudede on Thu, Oct 22, 2009 at 11:56 AM

The Vancouver Sun reports:

There is life in the planet's expanding dead zones, say researchers, who have uncovered a remarkable microbe thriving in toxic waters off the B.C. coast.

The bacteria takes up carbon dioxide like a plant, consumes sulphide that is deadly to most other lifeforms, and exhales nitrous oxide which is a potent greenhouse gas.

The microbe may be small but it appears to be an important global player impacting the chemistry of both the atmosphere and the oceans, says lead researcher Steven Hallam, of the University of British Columbia, who likes to point out that it is microbes that "really rule the world."

But a human being is a nation of microbes. The genome is only a part of the picture. The real picture is a meta-genome. What rules the world? Life rules this world.

Wednesday, October 21, 2009

The Ares 1-X Rumbles to the Launchpad

Posted by Jonathan Golob on Wed, Oct 21, 2009 at 11:36 AM

Ares1x.jpg

The Ares 1-X rocket rumbled out to Launch Pad 39B in preps for an absolutely critical test launch next week. The Ares rocket is meant to replace the shuttle and provide a safer way to send people into orbit—cannibalizing components from both the shuttle program and the Saturn V rockets. This will be the tallest rocket launched since the Saturn V during the Apollo era.

Keep your eyes peeled on October 27th for the launch. It should be a good show, either way.

Thursday, October 15, 2009

The Strings of Life

Posted by Charles Mudede on Thu, Oct 15, 2009 at 4:51 PM

This passage about the epigenome, "the first manual to show how genes are orchestrated inside cells" (it appeared today in a science article in the Guardian)...

If the genetic code were a keyboard, the epigenome would be the pianist. Different chords become the various cell types, and all the notes have to be played perfectly to produce a healthy human being. Damage to the epigenome — the pattern of chemicals that controls our genes — has been linked to medical conditions as diverse as asthma, schizophrenia and cancer.
...this passage reminded me of Dr. Michio Kaku's description of String Theory:
So the particles we see in nature are musical notes; if the rubber bands vibrate one way, it’s called an electron; if it vibrates another way, it’s called a quark; if it vibrates another way, it’s called a neutrino. So we have a musical analogy. So, the melodies you could play on the string is the laws of chemistry; the harmonies of the string is what we call physics. The universe is a symphony of strings. And then the mind of God; the mind of God that so fascinated Einstein for the last 30 years of his life — the mind of God — we now have a candidate for it, believe it or not; it is cosmic music resonating through 11 dimensional hyperspace.


And also a passage from Gilles Delueze's short but brilliant essay "Spinoza and Us":

The important thing is to understand life, each living individuality, not as a form, or a development of each living individuality, but as a complex relation between differential velocities, between deceleration and acceleration of particles. A composition of speeds and slowness on a plane of immanence. In the same way, a musical form will depend on a complex relationship between speeds and slownesses of sound particles...

Biology, physics, and philosophy—it all comes down to music:

Come With Me If You Want to Live

Posted by Paul Constant on Thu, Oct 15, 2009 at 2:01 PM

The New York Times presents the most awesome theory ever about why the Large Hadron Collider hasn't worked properly:

Then it will be time to test one of the most bizarre and revolutionary theories in science. I’m not talking about extra dimensions of space-time, dark matter or even black holes that eat the Earth. No, I’m talking about the notion that the troubled collider is being sabotaged by its own future. A pair of otherwise distinguished physicists have suggested that the hypothesized Higgs boson, which physicists hope to produce with the collider, might be so abhorrent to nature that its creation would ripple backward through time and stop the collider before it could make one, like a time traveler who goes back in time to kill his grandfather.

If I knew science was this cool when I was a kid, I wouldn't be fucking around with books today.

(Via The Rumpus.)

One Superconducting Ring to Bind Them All

Posted by Jonathan Golob on Thu, Oct 15, 2009 at 8:51 AM

The United States power grid is currently (get it? get it!?) split into three distinct chunks: an Eastern interconnection, a Western interconnection (of which Seattle and Washington State are members) and Texas. Why is Texas separate from the rest? Why indeed.

EnergyGrids.jpg
  • Public Domain

Surplus power generated in one interconnection, at this time, cannot be transferred to another. Further, the parts of the continent most promising for wind, solar and geothermal power (i.e. the greenest power choices available right now) are far from where the bulk of power is consumed (the East and West coasts).

Enter the Tres Amigas project—a plant build a superconducting triangle of powerlines to connect these three grids. Using high temperature superconductors allows the power to be transmitted as direct current with similar efficiencies to alternating current. (Mashing together alternating currents from disparate grids is quite problematic, due to issues of phase. Using DC to connect the grids alleviates this problem. Superconductors alleviate some of the inefficiencies of transmitting DC over long distances.)

This is good news from the perspective of green energy. Connecting the East and West coasts to the areas most promising for wind and solar power will boost the economic viability of such projects in the near future. In the negative, this allows for all sorts of new games to be played by energy traders in the largely unregulated energy market.

Friday, October 9, 2009

The Scientific Method

Posted by Dan Savage on Fri, Oct 9, 2009 at 2:30 PM

The feminized/masculinized guy from that study doesn't do it for me—ovulating or not, I'm just not into him (why does his fro grow when he gets masculinized?)—and, hey, it's not sound science if an experiment can't be duplicated to test the reliability of the results. So here in the interest of science...

2boyspillstudy.jpg

I want to fuck...

I am..

The results of Slog polls are scientifically valid and legally binding.

Re: In About Twelve Hours, We Smash a Part of the Moon

Posted by Grant Brissey on Fri, Oct 9, 2009 at 1:34 PM

Well, I guess I'm glad that I was too lazy to stay up until 4:30 am or get out of bed at 4:30 am to watch the LCROSS impact on the moon:

NASA's much anticipated LCROSS mission sent two spacecraft "bombing" into the moon early this morning. The craft successfully struck their target, a crater thought to harbor frozen water.

But the much-hyped moon show that had been expected to accompany the impact, however, turned out to be a flop—no billowing plumes of dust and ice visible through backyard telescopes or on NASA TV. The low-impact impact had one NASA expert musing that LCROSS may have struck a "dry hole."
Four minutes later LCROSS (Lunar Crater Observation and Sensing Satellite) performed its own kamikaze dive—the final act in its mission to detect evidence of water ice in the moon's shadowed craters.

Whether or not sky-watchers could see the LCROSS crashes, NASA insists they happened.

The only video I can find on the thing is sort of long and boring, and contains exactly zero explosions, but here it is:

Anyone else got interesting photos, video, or whatevers on LCROSS, let us know in the comments.

UPDATE: Wise commenter Peter F says:

The plume was pretty much invisible, even through observatory telescopes (haven't seen the Hubble observation yet) but NASA thinks they got the spectroscopic data they wanted from the instrumentation, though it will take a while to process.

And commenter Pissy Mcslogbot posted this image of the impact:

melies.gif

Via National Geographic

Re: Are You a Lady? On the Pill? Engaged To Be Married?

Posted by Dan Savage on Fri, Oct 9, 2009 at 12:59 PM

boysboysboys.jpg

Earlier in the week I wrote up the results of a study that showed that women who were on the pill when they were dating may wind up partnered with mates they're not all that into once they go off the birth control pill. The pill suppresses ovulation and studies have shown that ovulating women prefer men who are more masculine and "more... genetically unrelated," like the butch guy on the right; women who aren't ovulating prefer guys who are more feminine and genetically more similar, like the pansy on the left. From my post:

Alvergne and Lummaa theorize that all those suppressed ovulations may have dire consequences where sexual compatibility and long-term marital success are concerned. It can't be pleasant, after all, to realize you're not as attracted to your spouse as you thought you were once you stop taking the pill. And couples who are genetically similar—the kind of pairings the pill promotes—are more likely to have infertility issues. Which is, um, also bad. And then there's this: since men have been shown to find ovulating women more attractive, "...the use of oral contraceptives may influence a woman’s ability to attract a mate by reducing attractiveness to men, thereby disrupting her ability to compete with normally cycling women for access to mate."

I wrote the authors of the study—Dr. Alexandra Alvergne and Dr. Virpi Lummaa of the University of Sheffield—asked what they thought its implications were. Should women switch to the IUD? Should an engaged woman go off the pill to make sure she's not marrying a too-genetically-similar swish? Should we, you know, panic? Dr. Alvergne wrote me right back... but her email wound up in my spam folder. (Sorry about that, Dr. Alvergne.) Her letter—and her answers—after the jump...

Continue reading »

The HIV Vaccine... Success

Posted by Jonathan Golob on Fri, Oct 9, 2009 at 12:28 PM

Sixteen thousand people volunteered for the study—primarily Thai sex workers and IV drug users from the general population of two Thai provinces. All received condoms, HIV prevention counseling, and an offer for HAART therapy if they became positive. Eight thousand received a placebo shot, the other half six doses of two distinct (and previously failed) HIV vaccines. About five years later, 74 of the placebo recipients were newly HIV positive. Twenty-three fewer, 51 total, among the vaccine recipients were now HIV positive. It was a statistically significant reduction in infection among the vaccinated.

After years of struggle, and some truly distressing failures, this is the one and only successful HIV vaccine trial.

It definitely was an odd approach. Take two failed vaccines, combine them together, and see if they'll work. The first vaccine stuffed into a tamed Canarypox virus some of the critical functional proteins of the HIV virus. (Canarypox is in the same broad family of viruses that includes Smallpox. Birds are the desired home of Canarypox; it's capable of getting into human cells, but not properly replicating itself once in. As such, it has the ideal vaccine combination of really pissing off the human immune system while being incapable of causing injury.) The second, booster, vaccine was simply some of the purified and isolated surface protein (gp120) from the HIV virus. (This booster vaccine is a bit like going around the human immune system with a mugshot of the HIV virus. The isolated protein is incapable of causing disease, but gives the whiff of what the real deal is like.) When the study was first proposed, parts of the scientific community were non-plussed. Isn't zero times zero still zero?

Nope, it's one third. What do you do with a vaccine that only works sometimes, or only for some? For a vaccine to be considered clinically useful (i.e, after the shots are done, you can feel confident in telling someone they are vaccinated and protected against the infection), you'd hope to have at least 70-80% of those vaccinated to be protected. (Herd immunity takes care of the rest of the risk, eventually.) Further, this vaccine combination (bizarrely) failed to produce neutralizing antibodies even in the successfully vaccinated.

For the next few months and years, the results of this study will be torn into, trying to answer some of these questions. In the meantime, this is an extremely heartening sign—indicating a real potential to salvage other failed vaccines into successful combination therapies.

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