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Tuesday, March 5, 2013

Levamisole: Still Around, Still Making People Sick (In Case You Were Wondering)

Posted by on Tue, Mar 5, 2013 at 4:01 PM

A smidgen of real scientific research about levamisole in cocaine (instead of our decidedly nonscientific, shoestring journalism) is trickling onto the web. This study for the Annals of Emergency Medicine tracked people who wound up in US hospitals between mid-October 2009 and the following May. (The wheels of science turn slowly.)

Of the 46 potential cases reported from 6 states, half met eligibility criteria and had medical chart abstractions completed (n=23; 50%). Of these, close to half of the patients were interviewed (n=10; 43%). The average age was 44.4 years; just over half were men (n=12; 52%). The majority of patients presented to emergency departments (n=19; 83%). More than half presented with infectious illnesses (n=12; 52%), and nearly half reported active skin lesions (n=10; 44%). The majority of interview respondents used cocaine greater than 2 to 3 times a week (n=9; 90%), used cocaine more than 2 years (n=6; 60%), and preferred crack cocaine (n=6; 60%). All were unaware of exposure to levamisole through cocaine and of levamisole's inherent toxicity (n=10; 100%).

Our anecdotal evidence showed that levamisole poisoning was more frequent in regular users and in crack users—but I'm surprised to see that crack users make up only slightly more than half of this sample. And it's showing up in heroin, too, but only three percent of the seized herion, per the most recent numbers. (And three percent sounds small enough to be an accidental contamination or a whatever's-lying-around cut, not an actual economic strategy.)

And an anonymous commenter on The Stranger's first story about levamisole recently wrote:

Levamisole here in vancouver canada is mostly used to cut crack , because they doble their money , if a dealer cooks one ounce of coke, he adds another ounce of levamisole to it , becoming all together two ounces , and the users cant tell abd they think its base rock because they see only oil in the pipe and no dust left from the old cut that was baking soda .. Thats the reality of why they add levamisole to cocaine here in vancouver .. They sell the levamisole here for 1000 per kilo ..

That matches one of the theories we'd originally proposed—that levamisole makes a good cut, even though it's rarer than something like baking soda—because it has a chemical relationship with cocaine that passes street tests. Dealers (on a corner level or on an international level) who use purer-seeming cuts will be more popular than dealers who use obvious cuts.

But official sources—medical, governmental—have yet to officially solve the mystery of the tainted cocaine.

 

Comments (7) RSS

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Dougsf 1
Originally it didn't make sense to me why cocaine seized at the border would contain levamisole, since obviously it'd make more sense to smuggle smaller, more concentrated amounts, then cut for profit after shipment.

But what if there were another player in the supply chain—somewhere between manufacturing and smuggling. If that were the case, it would incentivize the use of levamisole in production, with makers trying maximize the pounds of cocaine they get on the truck.

Or another variation on the same idea, could the cartels be as sophisticated as any major corporation (or cocktail bar)—where the runners are billed for what they left with? It would be a good way for the manufacturers to maximize cash in hand vs. losing all that potential revenue down the supply chain.

I really would have no idea, but I'm all hopped up on green tea and this kinda makes sense to me.
Posted by Dougsf on March 5, 2013 at 4:26 PM
Supreme Ruler Of The Universe 2

Remind me again why people who think vaccines could possibly cause autism are stupid?

Your Kid Probably Doesn't Need Antibiotics

Every year, more and more children with viral illnesses are given unnecessary antibiotics, and as a result, the bacteria floating around in our bodies get exposed to those antibiotics and evolve, gaining resistance to even our most powerful antibiotics. Reports of these drug resistant bacteria are increasingly alarming.


http://www.theatlantic.com/health/archiv…
Posted by Supreme Ruler Of The Universe http://www.you-read-it-here-first.com on March 5, 2013 at 5:00 PM
rob! 3
@2, vaccines prevent disease by giving the immune system an early heads-up; antibiotics (sometimes) cure bacterial infections by directly interfering with the bacteria.

Also, there's no credible scientific evidence that vaccines cause autism; there are mountains of scientific evidence that careless use of antibiotics leads to the emergence of antibiotic-resistant strains.
Posted by rob! http://www.youtube.com/watch?v=QZBdUceCL5U on March 5, 2013 at 5:41 PM
Dougsf 4
@2 - Why do you need reminding? There never was a link.
If you want to read the 1,000th article on exactly how that is the case, and always has been, have at it.
http://gizmodo.com/5885757/vaccines-dont…

The only segue I can possible see between this and article you posted is the noting of the over-protective parent having far-reaching consequences on our society. What that has to do with Brendan's article is anyone's guess, 'cept maybe the link between certain drug abuse and paranoia.
Posted by Dougsf on March 5, 2013 at 5:44 PM
rob! 5
@4, I can understand someone imagining parallels between vaccines and antibiotics if the different modes of action (which I did not really clearly distinguish @3) are not understood and results are seen in the vaguest possible terms as an attempt to treat followed by unintended consequences, like the release of cane toads in Australia.

By and large, @2, vaccines either work or they don't in an individual recipient, starting with a relatively small number of infectious particles (such as when you inhale some particles of another person's sneeze). The presence of antibiotics, on the other hand, provides strong selective pressure on an already-large number of infectious particles, either those causing a diagnosed bacterial illness or "bystanders" in an illness caused by something else; with those large numbers of bacteria, the chances are higher that some will have a mutant genetic sequence that will allow them to reproduce even in the presence of the antibiotic. That's also why people are told to take their full prescribed course of antibiotics—if you stop as soon as you feel better, the small number of resistant bacteria can expand to overwhelm you (and spread to others) before your body can eliminate them by other means.
Posted by rob! http://www.youtube.com/watch?v=QZBdUceCL5U on March 5, 2013 at 6:33 PM
sirkowski 6
But wasn't it reported earlier that the Levamisole came from the source?
Posted by sirkowski http://www.missdynamite.com on March 5, 2013 at 10:08 PM
treacle 7
@6 - Yes. I don't think Brendan is contradicting that, only adding that this commenter claims that levamisole is also added in the production of crack in Vancouver.

@1 - "Cut for profit after shipment" ... well that would depend on who is receiving the shipment, and what they think it is. If the original shipper can ship 3/4 cocaine and 1/4 levamisole, and the receiving party in the US thinks it's 100% cocaine, then the shipper makes better profits. I'm not an expert, but I kinda doubt the cartels are in such close control of the receiving parties such that cutting with levamisole after shipping makes much sense or profits for the shippers. So they make the profits cutting early in the game. Other people cut later and make their own profits from that.

@2 - You know, the thing with giving kids antibiotics at all is that they destroy healthy gut flora as well, which may put the kids on a lifetime track of negative health conditions.
Posted by treacle on March 6, 2013 at 12:30 PM

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