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Thursday, November 29, 2012

AHHHH!!! Axiron Has the Most Disturbing Possible Side Effect in the History of Possible Side Effects

Posted by on Thu, Nov 29, 2012 at 9:22 AM

Side-effect disclaimers are generally a laff-riot (unless you're the target demographic), but this commercial for Axiron (embedding not allowed; I wonder why), which is testosterone therapy that men can paste onto their armpits, just screams "wrong." To wit: "Women, especially those who may become pregnant, and children should avoid contact where Axiron is applied, as unexpected signs of puberty in children or changes in body hair or acne in women may occur."

Look, I'm all for dudes getting their junk fixed if it doesn't work, but YOWZA—that's messed up, Jack! What if little Johnny gets into the medicine cabinet and thinks this stuff is shaving cream? Or little Janie decides to play makeup? I'll tell you what happens: PUBIC HAIR BEARD. Just swallow a pill or take the injection, pls. How much harder is that? In other news, I got cable last weekend (which is how I saw this most disturbing commercial), and I basically haven't left the house since.

 

Comments (41) RSS

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1
That's going to be true of pretty much any testosterone therapy, given that that's what testosterone does.
Posted by digitalwitch on November 29, 2012 at 9:35 AM
Canadian Nurse 2
I'm not a big fan of having sex with someone using a product that made their armpits off-limits.
Posted by Canadian Nurse on November 29, 2012 at 9:43 AM
3
This was featured in one of the chapters in Jesse Bering's "Why is the Penis Shaped Like That": the story of a baby boy who sprouted pubic hair and started having frequent erections because he was exposed to his dad's testosterone gel when the dad hugged him every night before bed. Fortunately the pubic hair fell out and he went back to being a normal baby once the dad was advised to change his routine.
Posted by I have always been... east coaster on November 29, 2012 at 9:44 AM
Sir Vic 4
@1 Yes and no. The problems with the test gel are kind of silly. Topical gels are the worst possible delivery mechanism for exogenous testosterone. Intramuscular injections are optimal, and can be done as little as once a week instead of daily gel rubs. Oral test has to be formulated in a way that is very damaging to the liver, so it is not a good long term option.

Unfortunately, all the well known and reliable injectible forms of test have been available for 30+ years and are therefore not patented by BigPharma. The need for Testosterone Replacement Therapy is still present, so they've had to come up with something they can sell at a profit, regardless of efficacy.

Topical test gel is fast acting, and fast ending, which is why pro athletes have taken it up. But it is nowhere near as effective as injected test and has its own set of side effects.

And for the adult man who needs TRT, what kind of trade-off is not being able to hug your wife & daughter? That would seem like a deal breaker for most men.
Posted by Sir Vic on November 29, 2012 at 9:48 AM
5
Dump the cable. In the long run it will do worse than give you a pubic hair beard.
Posted by concerned for your mental health on November 29, 2012 at 9:52 AM
Pope Peabrain 6
Do you have any idea what we spew into the Puget Sound? And children play in that water all the time.
Posted by Pope Peabrain on November 29, 2012 at 9:59 AM
7
Testo supplements are probably overprescribed for men under 50 and underprescribed for older hypogonadal men, who are at most serious risk of hip fracture. Men who get hip fractures generally don't do so well and typically die within the year. For a 60-year-old on supplements, the dangers of cross-contamination are a bit lower, as there usually aren't prepubescent children living in the household and the spouse is less likely to be of child-bearing age.

But remember, if grandpa is on transdermal testosterone gel, he shouldn't be hugging the grandkids unless he's wearing a shirt. And, wipe down the bathroom faucets before letting the kids use them.
Posted by Brooklyn Reader on November 29, 2012 at 10:00 AM
8
My partner used a testosterone gel as part of his HRT for a period of time, because he couldn't do the injections on himself and I wasn't around often enough to do it for him. We talked it over with his doctor, where he should put the gel, how long we should wait for touching one another afterwards, etc.

It was pretty easy to avoid.

Pills are a terrible way to take testosterone treatment, though. Your body doesn't absorb it as readily that way and it's a huge strain on the liver.
Posted by Zuulabelle http://www.mellophant.com on November 29, 2012 at 10:03 AM
Ph'nglui mglw'nafh Cthulhu R'lyeh wgah'nagl fhtagn 9
Kids. That's exactly why I only keep Percocet and horse tranquilizers in my medicine cabinet. If my kids accidentally swallow some, nothing bad will happen.

Axiron should be banned. For the children.
Posted by Ph'nglui mglw'nafh Cthulhu R'lyeh wgah'nagl fhtagn http://youtu.be/zu-akdyxpUc on November 29, 2012 at 10:05 AM
10
I take Axiron.

If you are a parent without a lockable medicine cabinet, you should get a lockable medicine cabinet.

If you are a woman dating a man that takes Axiron, ask him to take a shower before you touch his pits. Axiron is usually applied in the morning, and is absorbed within a couple hours. He can shower in the afternoon without hurting the efficacy of the drug. You can touch him after the Axiron has been washed away.

Low testosterone is difficult to treat.

Injections are intentional overdoses where you get a big hit in the beginning and then you completely run out over a period of days. The pill includes risks of blood clots, hepatitis and liver cancer.

I tried Androderm (a patch), AndroGel (a gel), Testim (a gel), and Striant (you hold it in your lip, like chew). I didn't have good results with any of these.

In spite of Axiron's seemingly yucky application procedure, I've found it to be the least revolting of the methods I've tried. For me, the results have been remarkably consistent, which was a problem with the other products I tried.

I hope you never have to know all that I've learned about what it means to be a testosterone patient.
Posted by SomeGuyInLynnwood on November 29, 2012 at 10:12 AM
11
@4 Partially valid observation. Testo supplements have side effects for the user, too, and those are worse in the higher doses. What the daily gels and patches accomplish is low-level but more constant dosing. Injections have a tailing dosage curve, very high in the first few days, falling off to too low at the end of two weeks. This has mood effects and other problems. The latest therapy involves subcutaneous pellets, which has more level dosing than injections, but requires minor surgery every 3 months.

The worst part of the gels is that the absorption level is around 10%, so 9 times more is getting into the environment than into the patient. In other words, a 5mg dose actually contains 50mg of testosterone (formulated as 5 grams of gel containing 1% testo), most of which ends up eventually on the shower floor and in the laundry, unless its turning into something else along the way (like estrogen?).
Posted by Brooklyn Reader on November 29, 2012 at 10:18 AM
12
50µg of clompihene citrate every two days brought my testosterone levels into boringly normal range, as per:

http://www.ncbi.nlm.nih.gov/pubmed/12904…

It might not work for you, but if it does, it's less creepy-on-the-skin than gels, less dangerous than pills, and less shoving-thing-in-your-armpits than this stuff.
Posted by Roderick Frederick Arnold Ronald Macarthur McBan CLII on November 29, 2012 at 11:10 AM
Will in Seattle 13
Going to be a lot of muscle-bound salmon come springtime in the Sound.
Posted by Will in Seattle http://www.facebook.com/WillSeattle on November 29, 2012 at 11:10 AM
Hawke 14
I've been hearing these ads for testosterone supplements and I wonder how many guys know that too much testosterone converts into estrogen. If anyone is using injectable or topical testosterone, they should get their levels checked regularly.
Posted by Hawke http://facebook.com/thehawke on November 29, 2012 at 11:12 AM
15
Awful lot of judgement around here about people trying to live with a legitimate, quantifiable medical condition.
Posted by jzimbert on November 29, 2012 at 11:27 AM
16
Any topical steroid carries these same risks. AndroGel, which has been on the market for a while, carries similar warnings.
Posted by Leo88 on November 29, 2012 at 11:40 AM
17
Yes to #15. Get a grip people.
Posted by drawn on November 29, 2012 at 12:18 PM
Rob in Baltimore 18
Parents who don't keep their medications, any medications, from their children, shouldn't have kids.
Posted by Rob in Baltimore http://www.wishbookweb.com/ on November 29, 2012 at 1:12 PM
Chelydra_serpentina 19
Good god. If they can deliver long-lasting hormonal birth control with a subcutaneous implant, why the fuck can't they do that with testosterone?

Slather goop into your armpits? Who thinks of these things?
Posted by Chelydra_serpentina on November 29, 2012 at 1:17 PM
20
Oh I don't know that it's the worst possible side effect. I took a med once where the most tricky side effect was that your skin falls off and you die. Not in patches or anything - it gets gangrenous, turns black, and sloughs, like a suit of clothes, a process that takes six weeks or so. You usually die before that, if you're lucky. Oh, and the only symptom that might warn you this is happening (and the process once begun is irreversible) is itchiness. Because you get a rash. On the inside of your skin, so it's invisible. Might I mention this med is for a mental illness? So.... that seems worse I guess. At least hormone side effects are kinda obvious and reversible.
Posted by I dunno on November 29, 2012 at 1:27 PM
21
Grant, the way that you portray treatments for hypogonadism here are insensitive, ignorant, and offensive. Axiron (and others) aren't discretionary drugs to "fix your junk"--they treat serious consequences like osteoporosis and depression. Furthermore, you'll find similar warnings on any transdermal drug, including transdermal estradiol. Sex hormone metabolism is complicated and varies wildly between individuals, and as @10 described, a delivery method that works well for one person may not work well for another.

Finally:
- There are far more acutely dangerous and widely used medications than Axiron. If your children think medicine is for funsies, you should probably keep it all locked up. (The same goes for kitchen knives, scissors, sewing machines, etc.)
- "Changes in body hair," means virilization/hirsuitism, not "pubic hair beard."
- Oral testosterone decimates the liver. Due to first-pass metabolism, it's not a practical delivery mechanism for long-term use. (Hypogonadism is generally a chronic condition, not one that you can fix with a short course of drugs.)
- High variability in serum testosterone levels makes injections intolerable for some people--in your language, it can be "much harder than that."

(To be fair, some people who are prone to dermatitis or who have high levels of peripheral 5-a-reductase don't tolerate the gels very well, either. It really depends on the individual.)
Posted by At long last, please have some decency on November 29, 2012 at 2:18 PM
22
Slate Pharma makes testosterone pellets (Testopel), which are implanted in the fat of the buttocks every 4-6 months depending on the individual. Pretty easy procedure, I do it in my office. There are safe oral preparations (Andriol) but not available in the US. There are also longer-acting injections (testosterone undecanoate) but also not available in the US. The point of Axiron is that by applying to the armpits instead of the chest/shoulder you're applying in a place kids are less likely to come into contact.
Posted by epunch on November 29, 2012 at 8:10 PM
23
If you have Low-T you would pretty much do anything to get your levels up. You suffer from depression that can not be controlled by medications, your bones thin and you are at a higher risk for heart failure and kidney failure! You have no quality of life!! Your whole family suffers! I had Prostate cancer 2yrs ago and a prolatin producing tomur on my pituatary gland. I have been taking medication to srink the tomur, but my testoserone keep dropping!! It is 63. But the doctors didn't want to give me Testoserone because of the cancer. However my PSA all are 0. I just got a prescription for Axiron and wow now not sure I can afford to even try it! $$$$ I am disabled and my wife just lost her job. So for all of you that have all the negitive things to say, you may feel different if it was happening to you and your family! I pray that you never have to go thru this!!
Posted by Papaw0713 on December 22, 2012 at 2:27 PM
24
All those that jump up and down about this medication keep in mind that it is medication and like any other medication, should be treated and used properly.

I am supposed to start using this medication as others had serious side effects and this particular medication may be a viable treatment. Yes, it is expensive, and yes, it is the 'new kid on the block' and it is used as last resort (at least in my case).

If you feel that you can't prevent cross contamination, or that you can't keep it away from reaching unintended individuals, then don't use it, but leave the rest of us, responsible patients, the option to use it.
Posted by Med that is needed on January 7, 2013 at 4:54 PM
25
Having been on Fortesta for11 months (one daily application on each inner thigh), the latest results are showing a decease in testosterone. Starting on the free one month trial of Axiron. Had blood draw today and will have another in one month.
Posted by Hub Capp on January 9, 2013 at 2:01 PM
26
#15 I don't see one person on here judging people who have a condition requiring testosterone treatments. Get over yourself.
Posted by EdNH on January 10, 2013 at 7:23 AM
27
U dummies ur soppose to cover the area with a t-shirt to to prevent exposure. N to the lady that has the sex issue with someone using, birth control is a hormone, so be careful how u judge.
Posted by informed on January 24, 2013 at 12:50 PM
28
You all are extremely ignorant. Pay attention, do some research and maybe you won't. Look like total dumb asses. Where did you get that its a gel or a cream? Really? Right there shows your level of intelligence. It is a formula that is mixed into rubbing alcohol. You pump the solution into a rubber applicator and rub it in under your arms. Its dry in less than 5 min and that's that. Its rubbing alcohol. I've been taking it for 6 months and the warning labels are for the stupid. After its dry in 2 -3 minutes its safe and your not going to spread it to anyone. What they need to come up with is a medicine for the incompetent people out there that leave remarks and are absolutely clueless to what they see or hear. No wonder this country is so messed up. Educate yourselves so you don look foolish. PATHETIC.
Posted by Brian Seibert on February 1, 2013 at 10:02 AM
29
To # 28...Now you know why there is a warning on fanbelts that states that the engine should be turned off before attempting to put the fan belt on....kinda makes you wonder.
anyway...
I just returned from my Dr. and the only real concern I have is the cost, around $ 450.00 for 90 ml. It is supposed to last for 30 days and I got 5 refills ($2250.00). Got the first one free with a coupon my Dr. had. He said that Lilly was really pushing this product, he did not say why. I'm sure it has to do with PROFIT. My insurance,(B/C B/S), will will not pick up the tab. I'll probably have to go to the injectable next month. Not really caring for this whole mess. Some of the comments on here have been a bit harsh but if ever they ever have to deal with such an issue I'm thinking that their tunes would change considerably. Again, thanks for your comment.
Posted by just this once, a little truth on February 4, 2013 at 12:02 PM
30
The transference of gels does not happen if you wear clothes over the application
Site. You will not instantly get a side effect if you come into contact with gel.repeated contact and you could have a side effect occurrence. Before contact wash application site. Dont run around naked/ have skin to skin contact(wear shirt, pants etc.)with kids present. I worry about those who do this. On the bright side you dont have to get a shot every 7-10 days to keep from having low testosterone and the gels mimic the bodys natural process or diurinal varation. One more thing to note that in females testosterone increases orgasmia and libido. So transfer just enough for this side effect but not a mustache! Make sure to put on clean dry skin and rub gel in vigorously and let dry before putting shirt on. Most gels need a couple of hours before swimming sweating bathing.
Posted by imfletch124 on February 7, 2013 at 11:26 AM
31
Does this highly "questionable" potion even WORK very well!??
Posted by RedOne on February 9, 2013 at 10:43 PM
32
As a 60 year old who used to struggle with low T, I have been using Androgel and/or Testim for five years (depending on what my insurance company will cover at the time), I can attest that they are necessary for quality of life. I have been blessed with no side effects, except for playing basketball three days a week, bicycling twice a week, and the overall energy that helps keep butt off the couch away and from the TV. And of course, being back in the saddle with my wife two to three times a week, that's the best! As far as side affects to our family...take a shower before sex, guys! Your wife will appreciate you in more ways than her not growing a beard :-). And common sense should tell you to keep your shirt on when hugging your grandkids. Finally, if the thought of putting a dab of clear gel on your shoulders or under your arms is disgusting to you...I'm assuming you never use alcohol, prescription drugs, food with preservatives, shampoo, conditioner, soaps, eye drops, deodorant, facial cremes, toilet paper, cough syrup, cold medicine, flu medicine, antacids, aspirin, sun tan lotion, bug spray, and the unending list of items with possible side effects that go in and on our bodies.
Posted by Still rockin! on April 10, 2013 at 6:58 AM
33
dude, you rock. #32 I'm so discouraged and you made me feel so good. I have zero problem with the application of axiron. I have been on it for 3 weeks, and feel no difference. I have noticed my testicles are slightly smaller, but i still cannot get an erection when i need to. If I do i cannot count on it to last at all. If i lose my erection it is simply gone. I worry that tacking axiron will make my testicles stop producing the amount they were making? Will i then be left with a dependency on artificial testosterone for life? I have all of the classic symptoms of low t, my number stink for my age i am half of the lowest number in my normal range. Tell me where this goes from here
Posted by number 9 on April 18, 2013 at 5:36 PM
34
I really find some of these comments quite insulting. I'ma 64 year old man, and for a reason not yet discovered my testosterone level dropped to a low of 18 (a normal range is 250 to 1000) and I was constantly tired and sometimes slept for 20 hours a day. Also, the mood swings were terrible -- I sometimes compared myself to those poor women who have severe PMS. I tried oral, but, strangely, it had virtually no effect at all, not even at the highest reccomended dosage. I then switched to Androgel. My last test showed a count of 550 and I feel alive again. I sleep normal hours and have the energy to get through my day without even a nap. Also, I now remember what sex was all about, and that's been rather enjoyable, to be honest!
Posted by cvmoreau on April 29, 2013 at 3:48 PM
35
I use injectable testosterone mostly because I cannot afford to pay a minimum of 350 dollars a month for androgel. Big pharma is only about the almighty dollar, not about the health and well being of the public. The cost of drugs such as androgel is a reflection not of research or production costs, rather it is a result of the massive level of advertising that goes along with any drug that relates in any way with the male sex organ. As an example, when was the last time you watched an hour of news without having to suffer through three or more boner pill commercials ? The actual cost of a product like androgel is probably more like 90 dollars a liter than 350 dollars for 90 ml.. I haven't experienced any noticeable mood or energy swings over the two week period between injections.
Posted by deejay on April 30, 2013 at 7:32 PM
36
I have been on injections 300mg every two weeks for two months. Free testosterone lab test taken post injection 3 day (peak)and post injection 14 day (trough) were as follows
3 day after
Testosterone 1865
Free test 454
14 day after
Testosterone 319
Free testosterone 54
Doc says axiron will provide steady state of an estimated 500 testosterone score for me with 3 swipes of 30mg.
I am 39 single father with a 16 month old baby.
Doc says put a tshirt on after axiron applicstion and you are fine. I am told it is not dangerous on skin 2-3 hours after. I do not think anyone should worry and if you wife or girlfriend grows a beard than wear an extra tshirt. This stuff is suppose to help. Testopel pellets is still best at $500 every 4 months cost.
Low t sucks and this or anything helps. Good luck everyone and happy ball shrinkage
Posted by King flow on May 3, 2013 at 6:21 PM
37
I'm a 37 year old cancer survivor and require testosterone replacement therapy. Androgel was great, no problems there - I am just trying Axiron for the 30 day trial and will be checked in a month to make sure the levels at this application have started to show results in my bloodwork.. I've been on a 9 month hiatus from T replacement therapy and it's clear how much of a difference this has made.

And to those making the ridiculous comments about side effects, about T replacement not being necessary, or just plain idiots who make comments like the above just because they enjoy the little clicky-noises the keyboard makes - bite me. It must take balls to make such a spectacle of yourself, in which case.. you don't need Axiron.. so piss off and contribute something smart to the discussion..

Posted by thebarbaricnoodle on May 3, 2013 at 11:14 PM
38
I'm a 37 year old cancer survivor and require testosterone replacement therapy. Androgel was great, no problems there - I am just trying Axiron for the 30 day trial and will be checked in a month to make sure the levels at this application have started to show results in my bloodwork.. I've been on a 9 month hiatus from T replacement therapy and it's clear how much of a difference this has made.

And to those making the ridiculous comments about side effects, about T replacement not being necessary, or just plain idiots who make comments like the above just because they enjoy the little clicky-noises the keyboard makes - bite me. It must take balls to make such a spectacle of yourself, in which case.. you don't need Axiron.. so piss off and contribute something smart to the discussion..

Posted by thebarbaricnoodle on May 3, 2013 at 11:16 PM
39
I just saw an ad for Axiron. The first thing that went through my mind was how easily this could be mistaken for underarm deodorant. If someone needs topical ht then do what you have to do. Just make sure that not only is it out of reach of any children, but clearly labeled as a form of testosterone. Preferably with a large prescription label clearly stating its contents. Can never be too careful.
Posted by nwportgirl on May 5, 2013 at 4:50 PM
40
You people need to worry about your own kids and make sure all your partying drugs are in let's say the same place you put guns. Men and women alike need this treatment. I have been on shots for ten years because my testicals quit making test. All my kids know I was on a medication for this without all details and they know not to go into my area where I keep it. I have tried all the gels, but never could achieve the range where I am to be at for my age. I do the shots to myself and take a ester blocker plus hcg so the testicles don't shrink. With that combo blood work is always good checking psa levels and yes, you know the good old manual test. Maybe this axiron is the real deal it's like putting on deodorant.
Posted by Lunger on May 7, 2013 at 5:40 AM
41
I have found this all very interesting reading. I have been on Testosterone replacement therapy for 15 years due to hypogonadism. Started on patches which, in the Australian heat kept falling off and caused a lot of itching. Levels stayed low. Started on Sustanon injections for many years at ten day intervals. My darling wife was trained by the GP to do it for me. I got huge highs then lows, became a grumpy old man, Then, due to constant stealing of shipments of the drug the Government banned it. That was due to the bodybuilders and the motorcycle gangs. Was then given Reandron injections which was the beginning of my problems. Slowly my Creatine levels rose along with my red blood cell count. Off to the Renal physician and Haematologist for exhaustive blood tests. After nine months my levels had fallen due to ceasing Reandron and I'm normal. My pharmacist made up a 10% Testosterone Cream which I have been applying 5 mils a day. My arms and chest end up being covered in the cream and it takes 30 minutes to dry.
A company in Australia (Acrux) has been working on transdermal application of drugs for years and invented Axiron and after many trials here sold the rights to market to Lilly's. I have seen the American TV ads (medicines are not allowed to be advertised on tv in Australia) and found it amusing that half the ad is all warnings. I know the reason that you put it under your armpits because there is less chance of it coming into contact with another. Americans love to sue each other. The liquid dries very quickly and brief contact by another would cause no harm. Only prolonged or repeat contact would. As human beings we are responsible for our actions and it is simple to remember you use it and if your girl wants to suck your armpits have a shower before.
I have now switched from the cream to Axiron and have never been happier with good results although it will take a few weeks to build up in my body. It took six months for my body to clear the Reandron. Hope this helps.
More...
Posted by Michael2 on May 21, 2013 at 3:21 AM

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