In 1922 he worked on the Valparaiso Messenger before moving to Washington, where he became a correspondent for several newspapers, including the Cedar Rapids Gazette and the Houston, Texas, Chronicle. He worked for a while at the Washington Herald.
He was the author of a syndicated column "Information Roundup," and became an expert on Shakespeare and the Bible, as well as American history and politics. He was also an associate editor of the weekly magazine Pathfinder. He was elected president of the National Press Club in 1935.
He wrote ten informational books. He intended to write a trilogy of books about America comprised of A Book About American History, A Book About American Politics, and A Book About American Government. He was working on this last book in September 1952 when he died at the age of fifty-five. He had been in poor health with a bad heart and diabetes and had been virtually blind for about a year at the time of his death.

George Stimpson, an Iowa farm boy who became a Washington newspaper correspondent and president of the National Press Club, collects facts with the same zeal with which some men collect stamps, match covers or dollars. With a "curiosity" more insatiable than that of the elephant's child he has spent much of his life asking questions and finding answers. With omnivorous and voracious hunger he has gathered unto himself information upon a hundred subjects without apparent order, plan or discrimination. The trivial and useless seem to interest him as much as the fundamental and important, the odd and fascinating as much as the dull and obvious. Examples of all these varieties may be found in Mr. Stimpson's "A
Book About a Thousand Things."